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ABT 737

Cat. No. 6835 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
化学名： 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ABT 737

ABT 737 is a high affinity Bcl-2 family inhibitor (Ki ≤ 1nM for Bcl-XL, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC50 < 1 μM) and multiple myeloma cells (IC50 = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.

技术数据 for ABT 737

分子量 813.43
公式 C42H45ClN6O5S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 852808-04-9
PubChem ID 11228183
InChI Key HPLNQCPCUACXLM-PGUFJCEWSA-N
Smiles CN(CC[C@@H](NC1=C([N+]([O-])=O)C=C(S(=O)(NC(C2=CC=C(N3CCN(CC3)CC4=C(C5=CC=C(C=C5)Cl)C=CC=C4)C=C2)=O)=O)C=C1)CSC6=CC=CC=C6)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ABT 737

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 81.34 100

制备储备液 for ABT 737

以下数据基于产品分子量 813.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.23 mL 6.15 mL 12.29 mL
5 mM 0.25 mL 1.23 mL 2.46 mL
10 mM 0.12 mL 0.61 mL 1.23 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

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参考文献 for ABT 737

参考文献是支持产品生物活性的出版物。

Oltersdorf et al (2005) An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 425 677 PMID: 15902208

van Delft, MF et al (2006) The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 10 389 PMID: 17097561

Kline et al (2007) ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia 21 1549 PMID: 17460700

If you know of a relevant reference for ABT 737, please let us know.

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关键词: ABT 737, ABT 737 supplier, ABT737, bcl, family, bcl-2, bcl-w, bcl-xl, inhibitors, inhibits, BH3, mimetics, apoptosis, inducers, induces, Bcl-2, Family, 6835, Tocris Bioscience

1 篇 ABT 737 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ABT 737 的部分引用包括：

Jerome et al (2022) Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Cell Metab 34 1248-1263.e6 PMID: 35987203

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