ACHP

Cat. No. 4547 12 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective IKKα and IKKβ inhibitor

化学名： 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile

纯度： ≥97% (HPLC)

说明书

引用文献 (12)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ACHP

ACHP is a IκB kinase inhibitor (IC₅₀ values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC₅₀ values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis. Also inhibits STAT3 signaling in NSCLC in vitro.

技术数据 for ACHP

分子量	364.44
公式	C₂₁H₂₄N₄O₂
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	406208-42-2
PubChem ID	65663
InChI Key	SRVFFFJZQVENJC-IHRRRGAJSA-N
Smiles	OC1=CC=CC(OCC3CC3)=C1C2=NC(N)=C(C#N)C(C4CCNCC4)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ACHP

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	7.29	20

制备储备液 for ACHP

以下数据基于产品分子量 364.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	13.72 mL	68.6 mL	137.2 mL
1 mM	2.74 mL	13.72 mL	27.44 mL
2 mM	1.37 mL	6.86 mL	13.72 mL
10 mM	0.27 mL	1.37 mL	2.74 mL

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产品说明书 for ACHP

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ACHP

参考文献是支持产品生物活性的出版物。

Sanda et al (2005) Growth inhibition of multiple myeloma cells by a novel IκB kinase inhibitor. Clin.Cancer Res. 11 1974 PMID: 15756023

Murata et al (2004) Synthesis and structure-activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents. Bioorg.Med.Chem.Lett. 14 4019 PMID: 15225718

Lee et al (2019) The IκB kinase inhibitor ACHP targets the STAT3 signaling pathway in human non-small cell lung carcinoma cells. Biomolecules 9 875 PMID: 31847229

If you know of a relevant reference for ACHP, please let us know.

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