AKT Inhibitor IV

Cat. No. 5985 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates

化学名： 6-(2-Benzothiazolyl)-1-ethyl-2-[(1E)-2-(methylphenylamino)ethenyl]-3-phenyl-1H-benzimidazolium iodide

纯度： ≥98% (HPLC)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AKT Inhibitor IV

AKT Inhibitor IV promotes hyperphosphorylation of Akt (Protein kinase B), decreases phosphorylation of Akt substrates, and inhibits FOXO1a nuclear export (IC₅₀ = 625 nM in PTEN-null cells). AKT Inhibitor IV inhibits the proliferation of several cells lines (IC₅₀ values are <1.25 μM, 320 - 670 nM and 340 nM for 786-O, HeLa and Jurkat cells, respectively). This compound also displays broad antiviral activity against negative-stranded RNA viruses; inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC₅₀ = 520 nM). In HeLa cells, AKT Inhibitor IV accumulates in mitochondria, disrupting morphology and increasing ROS production. At high concentrations (10 μM), AKT Inhibitor IV activates the unfolded protein response and apoptosis in HEK293T cells.

AKT Inhibitor IV is weakly fluorescent upon irradiation with UV light (excitation/emission maxima λ ~ 388/460; quantum yield = 0.0016).

技术数据 for AKT Inhibitor IV

分子量	614.54
公式	C₃₁H₂₇IN₄S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	959841-49-7
PubChem ID	5719375
InChI Key	NAYRELMNTQSBIN-UHFFFAOYSA-M
Smiles	CCN1C2=CC(C3=NC4=CC=CC=C4S3)=CC=C2[N+](C5=CC=CC=C5)=C1/C=C/N(C6=CC=CC=C6)C.[I-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AKT Inhibitor IV

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	61.45	100

制备储备液 for AKT Inhibitor IV

以下数据基于产品分子量 614.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.14 mL	16.27 mL
5 mM	0.33 mL	1.63 mL	3.25 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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产品说明书 for AKT Inhibitor IV

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AKT Inhibitor IV

参考文献是支持产品生物活性的出版物。

Kau et al (2003) A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell. 4 463 PMID: 14706338

Sun et al (2011) Synthesis and biological evaluation of analogues of AKT (protein kinase B) inhibitor-IV. J.Med.Chem 54 1126 PMID: 21319800

Meinig & Peterson (2015) Anticancer/antiviral agent Akt inhibitor-IV massively accumulates in mitochondria and potently disrupts cellular bioenergetics. ACS.Chem.Biol. 10 570 PMID: 25415586

If you know of a relevant reference for AKT Inhibitor IV, please let us know.

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关键词: AKT Inhibitor IV, AKT Inhibitor IV supplier, AKTIV, Akt, inhibitor, IV, Chembridge, 5233705, anticancer, antiviral, 681281-88-9, (Protein, Kinase, B), Non-selective, Antivirals, 5985, Tocris Bioscience

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Pathways for AKT Inhibitor IV

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.