Akti-1/2

Name: Akti-1/2
Brand: Tocris Bioscience
SKU: 5773
Rating: 4.5 (2 reviews)

Cat. No. 5773 11 篇引用文献 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective dual Akt1 and 2 inhibitor

别名： Akt Inhibitor VIII

化学名： 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one

纯度： ≥98% (HPLC)

说明书

引用文献 (11)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Akti-1/2

Akti-1/2 is a potent and selective dual Akt1 and 2 inhibitor (IC₅₀ values are 50 and 210 nM, respectively). Selective for Akt1 and 2 over a panel of other tyrosine and serine/threonine kinases. Sensitizes LnCaP cells to TRAIL (TNF-related apoptosis-inducing ligand) induced apoptosis. Also enhances CAR and TCR retroviral transduction of human T cells. Active in vivo.

技术数据 for Akti-1/2

分子量	551.64
公式	C₃₄H₂₉N₇O
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	612847-09-3
PubChem ID	10196499
InChI Key	BIWGYFZAEWGBAL-UHFFFAOYSA-N
Smiles	O=C1NC2=C(C=CC=C2)N1C(CC3)CCN3CC(C=C4)=CC=C4C5=NC6=CC(N=CN7)=C7C=C6N=C5C8=CC=CC=C8

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Akti-1/2

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	11.03	20 温和加热

制备储备液 for Akti-1/2

以下数据基于产品分子量 551.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	9.06 mL	45.32 mL	90.64 mL
1 mM	1.81 mL	9.06 mL	18.13 mL
2 mM	0.91 mL	4.53 mL	9.06 mL
10 mM	0.18 mL	0.91 mL	1.81 mL

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产品说明书 for Akti-1/2

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Akti-1/2

参考文献是支持产品生物活性的出版物。

DeFeo-Jones D et al (2005) Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members. Mol.Cancer Ther. 4 271 PMID: 15713898

Barnett et al (2005) Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem. J. 385 399 PMID: 15456405

Lindsley et al (2005) Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg.Med.Chem.Lett. 15 761 PMID: 15664853

Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297 PMID: 17850214

Klebanoff et al (2017) Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy. JCI Insight 2 e95103 PMID: 29212954

If you know of a relevant reference for Akti-1/2, please let us know.

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关键词: Akti-1/2, Akti-1/2 supplier, Akt1/2, inhibitors, inhibits, potent, selective, PKB, protein, kinase, B, sensitizes, apoptosis, viral, transduction, enhancer, enhances, Akt, Inhibitor, VIII, (Protein, Kinase, B), Protein, B/Akt, Viral, Transduction, Enhancers, 5773, Tocris Bioscience

11 篇 Akti-1/2 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Akti-1/2 的部分引用包括：

Viviana I et al (2019) Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease. J Neurochem 149 54-72 PMID: 30300917

Claudio et al (2022) PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism. Mol Oncol 16 188-205 PMID: 34535949

Aurélie et al (2022) Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion. Cancers (Basel) 14 PMID: 35954442

Lucie et al (2022) Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication. Viruses 14 PMID: 36146824

Adriano et al (2022) TSC22D4 interacts with Akt1 to regulate glucose metabolism. Sci Adv 8 eabo5555 PMID: 36269831

Margitta et al (2022) Pannexin-1 Activation by Phosphorylation Is Crucial for Platelet Aggregation and Thrombus Formation. Int J Mol Sci 23 PMID: 35563450

Perkins et al (2018) Autocrine-paracrine prostaglandin E₂ signaling restricts TLR4 internalization and TRIF signaling. Nat.Immunol. 19 1309 PMID: 30397349

Kodaka et al (2020) Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells. PLoS One 15 e0231265 PMID: 32267872

Zhong et al (2018) Tyro3 is a podocyte protective factor in glomerular disease. JCI Insight 3 PMID: 30429374

Anna M et al (2021) Gαq activation modulates autophagy by promoting mTORC1 signaling. Nat Commun 12 4540 PMID: 34315875

Charles G et al (2021) EGFR Activates a TAZ-Driven Oncogenic Program in Glioblastoma. Cancer Res 81 3580-3592 PMID: 33910930

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Akti-1/2 的评论

平均评分: 4.5 (基于 2 条评论。)

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Akti-1/2 blocks LPA-mediated COX-2 expression.

By Peter Cruz on 12/13/2018

分析类型： In Vitro

种属： Human

细胞系/组织： Osteosarcoma

Human osteosarcoma cells were incubated with 10 μM Akti-1/2 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Akti-1/2 abolished LPA-induced COX-2 expression.

Akt-1/2 blocks 15d-PGJ2-induced Akt phosphorylation.

By Christopher Trummer on 10/15/2018