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AMG 900

Cat. No. 7865 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent pan-Aurora kinase inhibitor
化学名： N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AMG 900

AMG 900 is a potent pan-Aurora kinase inhibitor (IC50 values are 1 nM, 4 nM, and 5 nM for Aurora C, B, and A, respectively). It is more than 10-fold selective for Aurora kinases over JNK2, Tie2, p38α, Met, and TYK2. AMG 900 inhibits autophosphorylation of Aurora A and B, as well as the phosphorylation of histone H3 on Ser in HeLa cells. AMG 900 inhibits proliferation of 26 tumor cell lines (EC50 ranges from 0.7 nM - 5.3 nM), including Paclitaxel (Cat. No. 1097)-resistant tumor cell lines. In an HCT116 tumor xenograft model, AMG 900 inhibits phosphorylation of histone H3 and tumor growth. It is orally bioavailable.

技术数据 for AMG 900

分子量 503.58
公式 C28H21N7OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 945595-80-2
PubChem ID 24856041
InChI Key IVUGFMLRJOCGAS-UHFFFAOYSA-N
Smiles N1=NC(C=2SC=C(C2)C)=C3C=CC=CC3=C1NC4=CC=C(OC=5N=CC=CC5C6=NC(=NC=C6)N)C=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AMG 900

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.04 10 温和加热

制备储备液 for AMG 900

以下数据基于产品分子量 503.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 19.86 mL 99.29 mL 198.58 mL
0.5 mM 3.97 mL 19.86 mL 39.72 mL
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL

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参考文献 for AMG 900

参考文献是支持产品生物活性的出版物。

Payton et al (2010) Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 70 9846 PMID: 20935223

If you know of a relevant reference for AMG 900, please let us know.

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关键词: AMG 900, AMG 900 supplier, AMG900, potent, selective, pan-Aurora, kinase, inhibitor, inhibit, inhibitors, inhibits, autophosphorylation, phosphorylation, histone, H3, Aurora, Kinases, Mitosis, 7865, Tocris Bioscience

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