AMG PERK 44

Cat. No. 5517 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective PERK inhibitor; orally bioavailable

化学名： 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride

纯度： ≥98% (HPLC)

引用文献 (8)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AMG PERK 44

AMG PERK 44 is a potent and selective PERK inhibitor (IC₅₀ = 6 nM). Exhibits >160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.

许可信息

By permission of the authors

化合物库 for AMG PERK 44

AMG PERK 44 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AMG PERK 44

分子量	561.07
公式	C₃₄H₂₈N₄O₂.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1883548-84-2
PubChem ID	121513867
InChI Key	RNAKBTDDCHJCMT-UHFFFAOYSA-N
Smiles	CC2=NC1=CC=C(C3=C(N)C(C(C4=C(C5=CC=CC=C5)N(C)N(C6=CC=CC=C6)C4=O)=O)=CC=C3C)C=C1C=C2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AMG PERK 44

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	11.22	20

制备储备液 for AMG PERK 44

以下数据基于产品分子量 561.07。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	8.91 mL	44.56 mL	89.12 mL
1 mM	1.78 mL	8.91 mL	17.82 mL
2 mM	0.89 mL	4.46 mL	8.91 mL
10 mM	0.18 mL	0.89 mL	1.78 mL

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产品说明书 for AMG PERK 44

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AMG PERK 44

参考文献是支持产品生物活性的出版物。

Smith et al (2015) Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK). J.Med.Chem. 58 1426 PMID: 25587754

If you know of a relevant reference for AMG PERK 44, please let us know.

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关键词: AMG PERK 44, AMG PERK 44 supplier, AMGPERK44, PERK, inhibitors, inhibits, potent, selective, protein, kinase, R-like, PKR, ER, orally, bioavailable, 5517, Tocris Bioscience