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Amphotericin B

Cat. No. 6930 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Forms monovalent ion channels in lipid bilyers; antifungal
化学名： (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
纯度： ≥90% (HPLC)
说明书
引用文献
评论
实验方案 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Amphotericin B

Amphotericin B forms nonselective monovalent ion channels within lipid bilayers. Amphotericin B binds ergosterol in the cell membrane. Antifungal and antiprotozoal.

For more information about how Amphotericin B may be used, see our protocol:

3D Culture of Lung Alveolar Cells

技术数据 for Amphotericin B

分子量 924.09
公式 C47H73NO17
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 1397-89-3
PubChem ID 5280965
InChI Key APKFDSVGJQXUKY-INPOYWNPSA-N
Smiles [H][C@]12C[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Amphotericin B

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.48 20

制备储备液 for Amphotericin B

以下数据基于产品分子量 924.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 5.41 mL 27.05 mL 54.11 mL
1 mM 1.08 mL 5.41 mL 10.82 mL
2 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.11 mL 0.54 mL 1.08 mL

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参考文献 for Amphotericin B

参考文献是支持产品生物活性的出版物。

Muruglia et al (2019) Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia. Nature. 567 405 PMID: 30867598

Gallis et al (1990) Amphotericin B: 30 years of clinical experience. Rev.Infect.Dis. 12 308 PMID: 2184499

Lewis (2011) Current concepts in antifungal pharmacology. Mayo Clin.Proc. 86 805 PMID: 21803962

If you know of a relevant reference for Amphotericin B, please let us know.

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关键词: Amphotericin B, Amphotericin B supplier, antifungal, monovalent, ion, channels, polyene, macrolide, Biochemicals, and, Molecular, Biology, Antifungals, 6930, Tocris Bioscience

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Amphotericin B 实验方案

以下实验方案包含使用 Amphotericin B（目录编号 6930）的更多信息。