API-1

Cat. No. 3897 4 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3897 has been discontinued.

View all Akt (Protein Kinase B) products.

说明： Selective Akt/PKB inhibitor. Antitumor

化学名： 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide

纯度： ≥96% (HPLC)

说明书

引用文献 (4)

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for API-1

API-1 is an Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo.

技术数据 for API-1

分子量	337.29
公式	C₁₃H₁₅N₅O₆
储存	Store at RT
纯度	≥96% (HPLC)
CAS Number	36707-00-3
PubChem ID	24773090
InChI Key	SPBWHPXCWJLQRU-FITJORAGSA-N
Smiles	O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CN=C3N)=C3C(C(C(N)=O)=C2)=O)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for API-1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for API-1

参考文献是支持产品生物活性的出版物。

Saglam et al (2016) Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells. Oncol.Lett. 12 2463 PMID: 27698814

Ren et al (2013) The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. Mol.Cancer 12 146 PMID: 24261825

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关键词: API-1, API-1 supplier, protein, kinase, b, pkb, akt, inhibitors, inhibits, antitumor, antitumour, apoptosis, BAX, BAK, Mcl-1, colorectal, cancer, cells, Akt, (Protein, Kinase, B), Protein, B/Akt, Apoptosis, Inducers, 3897, Tocris Bioscience

4 篇 API-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 API-1 的部分引用包括：

Jezierska-Drutel et al (2019) The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases. BMC Cancer 19 812 PMID: 31419957

Zhu et al (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. EMBO J 31 31 PMID: 22463935

Shamblott et al (2016) Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2(TRKB) signaling in the adult human exocrine pancreas. Cell Communication and Signaling 14 23 PMID: 27659207

Arslan and Yerer (2018) α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). Nutrients 10 PMID: 29799481

API-1 的评论

平均评分: 5 (Based on 1 Review.)

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Study of API-1 induction c-FLIP degradation and synergization with TRAIL to augment apoptosis.

By Anonymous on 01/16/2020

种属： Human

Study of API-1 induction c-FLIP degradation and synergization with TRAIL to augment apoptosis.API-1 effectively induced apoptosis in tested cancer cell lines including activation of caspase-8 and caspase-9.

Pathways for API-1

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.