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ArMan

Cat. No. 8869 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： DC-SIGN ligand used to target dendritic cells
化学名： N-(4-(((2R,3S,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenethyl)pent-4-ynamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ArMan

ArMan is an aryl mannoside targeting ligand that can be functionalised to the surface of virus like particles (VLPs) via click chemistry. Functionalised particles can be used to target DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin) dendritic cells to promote selective coengagement of DC-SIGN and TLR7, resulting in a Th1-type immune response. In vivo, immunization with VLP-ArMan-OvaI/II significantly inhibits tumor growth in a murine melanoma model.

技术数据 for ArMan

分子量 379.41
公式 C19H25NO7
储存 Store at -20°C
纯度 ≥98% (HPLC)
PubChem ID 170958390
InChI Key DJVWDLGJYGPTMN-IQRFUGTFSA-N
Smiles OC[C@@H](O[C@H](OC1=CC=C(C=C1)CCNC(CCC#C)=O)[C@H]2O)[C@@H](O)[C@@H]2O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ArMan

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.94 100

制备储备液 for ArMan

以下数据基于产品分子量 379.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.18 mL 26.36 mL
5 mM 0.53 mL 2.64 mL 5.27 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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参考文献 for ArMan

参考文献是支持产品生物活性的出版物。

Lensch et al (2024) Carbohydrate-lectin interactions reprogram dendritic cells to promote type 1 anti-tumor immunity. ACS Nano 18 26770 PMID: 39283240

Alam et al (2021) Glycan-modified virus-like particles evoke T helper type 1-like immune responses. ACS Nano 15 309 PMID: 32790346

If you know of a relevant reference for ArMan, please let us know.

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关键词: ArMan, ArMan supplier, ligands, dendritic, cells, specific, intercellular, adhesion, molecule-3, grabbing, nonintegrin, in, vivo, click, chemistry, virus-like, particles, arylmannoside, VLP, Toll-like, receptor, TLR, Biochemicals, and, Molecular, Biology, Receptors, 8869, Tocris Bioscience

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