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AS 2444697

Cat. No. 5430 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective IRAK4 inhibitor
化学名： N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AS 2444697

AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

化合物库 for AS 2444697

AS 2444697 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AS 2444697

分子量 432.86
公式 C19H20N6O4.HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1287665-60-4
PubChem ID 118719434
InChI Key FGNHLIIFEDYNFZ-UHFFFAOYSA-N
Smiles O=C(N)C2=NN(C=C2NC(C3=COC(C4=CC=NC(C)=C4)=N3)=O)C1CCOCC1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AS 2444697

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 8.66 20 温和加热

制备储备液 for AS 2444697

以下数据基于产品分子量 432.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 11.55 mL 57.76 mL 115.51 mL
1 mM 2.31 mL 11.55 mL 23.1 mL
2 mM 1.16 mL 5.78 mL 11.55 mL
10 mM 0.23 mL 1.16 mL 2.31 mL

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产品说明书 for AS 2444697

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for AS 2444697

参考文献是支持产品生物活性的出版物。

Chaudhary (2015) Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J.Med.Chem. 58 96 PMID: 25479567

Kondo et al (2014) Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats. Naunyn Schmiedebergs Arch.Pharmacol. 387 909 PMID: 25052043

Schmaderer and Heemann (2014) Blocking innate immunity to slow the progression of chronic kidney disease. Naunyn Schmiedebergs Arch.Pharmacol. 387 905 PMID: 25107563

If you know of a relevant reference for AS 2444697, please let us know.

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关键词: AS 2444697, AS 2444697 supplier, AS2444697, potent, selective, interleukin-1, receptor-associated, kinase, 4, IRAK4, inhibitors, inhibits, anti-inflammatory, renoprotective, Cytokines, IRAK, 5430, Tocris Bioscience

1 篇 AS 2444697 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AS 2444697 的部分引用包括：

Zhang et al (2018) Tumor-Stroma IL1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer. Cancer Res 78 1700 PMID: 29363544

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