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AS 605240

Cat. No. 3578 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3578 has been discontinued.

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说明： Potent and selective PI 3-kinase γ (PI 3-Kγ) inhibitor
化学名： 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for AS 605240

AS 605240 is a potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ) (IC50 = 8 nM). Displays 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

技术数据 for AS 605240

分子量 257.27
公式 C12H7N3O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 648450-29-7
PubChem ID 5289247
InChI Key SQWZFLMPDUSYGV-POHAHGRESA-N
Smiles O=C(/C(S3)=C/C(C=C2)=CC1=C2N=CC=N1)NC3=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for AS 605240

参考文献是支持产品生物活性的出版物。

Peng et al (2010) Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice. J.Pharmacol.Exp.Ther. 332 46 PMID: 19828878

Camps et al (2005) Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nature Med. 11 936

Wang et al (2009) Phosphoinositide 3-kinase γ inhibitor ameliorates concanavalin A-induced hepatic injury in mice. Biochem.Biophys.Res.Comm. 386 569

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关键词: AS 605240, AS 605240 supplier, AS605240, PI3Kgamma, PI3Kγ, PI, 3-kinasegamma, 3-kinaseg, 3-kinaseγ, phosphoinositide, 3, kinases, gamma, γ, Potent, selective, inhibitors, inhibits, inositol, lipids, signalling, signaling, orally, active, ATP-competitive, 3-Kinase, Inositol, Lipids, 3578, Tocris Bioscience

2 篇 AS 605240 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AS 605240 的部分引用包括：

Beauséjour et al (2012) Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis 17 566 PMID: 22402981

Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol 81 832 PMID: 22434859

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