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AT 101

Cat. No. 3367 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Downregulates Bcl-2 and Mcl-1; pro-apoptotic
化学名： (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AT 101

AT 101 is a R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.

化合物库 for AT 101

AT 101 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AT 101

分子量 518.56
公式 C30H30O8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 90141-22-3
PubChem ID 3503
InChI Key QBKSWRVVCFFDOT-UHFFFAOYSA-N
Smiles OC1=[C@]([C@]2=C(O)C(C(C=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)C(C)=CC4=C1C(C=O)=C(O)C(O)=C4C(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AT 101

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.37 20

制备储备液 for AT 101

以下数据基于产品分子量 518.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 9.64 mL 48.21 mL 96.42 mL
1 mM 1.93 mL 9.64 mL 19.28 mL
2 mM 0.96 mL 4.82 mL 9.64 mL
10 mM 0.19 mL 0.96 mL 1.93 mL

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产品说明书 for AT 101

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for AT 101

参考文献是支持产品生物活性的出版物。

Balakrishnan et al (2009) AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 113 149 PMID: 18836097

Kline et al (2008) R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. Exp.Hematol. 36 568 PMID: 18346839

Loberg et al (2007) In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia 9 1030 PMID: 18084610

If you know of a relevant reference for AT 101, please let us know.

按标靶查看相关产品

关键词: AT 101, AT 101 supplier, downregulates, Bcl-2, Mcl-1, proapoptotic, apoptosis, inducer, gossypol, Bcl, AT101, Family, Apoptosis, Inducers, 3367, Tocris Bioscience

1 篇 AT 101 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AT 101 的部分引用包括：

Chen et al (2016) Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. World J Gastroenterol 11 e0156145 PMID: 27203692

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该领域的文献

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