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AZ 13705339

Cat. No. 6177 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent PAK1 and PAK2 inhibitor
化学名： 2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZ 13705339

AZ 13705339 is a highly potent PAK1 and PAK2 inhibitor (IC50 values are 0.33 and 6 nM for PAK1 and PAK2, respectively). Displays >7500-fold selectivity for PAK1 over PAK4 (IC50 = 2.6 μM).

化合物库 for AZ 13705339

AZ 13705339 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AZ 13705339

分子量 629.75
公式 C33H36FN7O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2016806-57-6
PubChem ID 129909860
InChI Key WPFLVPJXKWCRQK-UHFFFAOYSA-N
Smiles CCS(=O)(C1=C(N2CCN(CC2)C)C=CC(NC3=NC=C(C(N(C4=CC(CO)=CC=C4C)CC5=C(C#N)C=CC=C5)=N3)F)=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZ 13705339

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 62.98 100
ethanol 12.6 20 温和加热

制备储备液 for AZ 13705339

以下数据基于产品分子量 629.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.94 mL 15.88 mL
5 mM 0.32 mL 1.59 mL 3.18 mL
10 mM 0.16 mL 0.79 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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参考文献 for AZ 13705339

参考文献是支持产品生物活性的出版物。

McCoull et al (2016) Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors. ACS Med.Chem.Lett. 7 1118 PMID: 27994749

If you know of a relevant reference for AZ 13705339, please let us know.

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关键词: AZ 13705339, AZ 13705339 supplier, AZ13705339, PAK1, PAK2, Group, I, inhibitors, inhibits, P21, activated, kinase, highly, potent, P21-activated, Kinases, 6177, Tocris Bioscience

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