AZ 3146

Pricing Availability   Qty
说明: Potent and selective Mps1 kinase inhibitor
化学名: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
纯度: ≥99% (HPLC)
说明书
引用文献 (13)
评论
文献 (2)

生物活性 for AZ 3146

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

许可信息

Sold for research purposes only under agreement from AstraZeneca UK Ltd.

化合物库 for AZ 3146

AZ 3146 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AZ 3146

分子量 452.55
公式 C24H32N6O3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1124329-14-1
PubChem ID 56973724
InChI Key YUKWVHPTFRQHMF-UHFFFAOYSA-N
Smiles CN(C1=CN=C(NC4=CC=C(OC5CCN(C)CC5)C=C4OC)N=C1N2C3CCCC3)C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZ 3146

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 11.31 25
ethanol 33.94 75

制备储备液 for AZ 3146

以下数据基于产品分子量 452.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 2.95 mL 14.73 mL 29.46 mL
3.75 mM 0.59 mL 2.95 mL 5.89 mL
7.5 mM 0.29 mL 1.47 mL 2.95 mL
37.5 mM 0.06 mL 0.29 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for AZ 3146

分析证书/产品说明书
选择另一批次:

参考文献 for AZ 3146

参考文献是支持产品生物活性的出版物。

Hewitt et al (2010) Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J.Cell Biol. 190 25 PMID: 20624899

Lan and Cleveland (2010) A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell.Biol. 190 21 PMID: 20624898

Maciejowski et al (2010) Mps1 directs the assembly of Cdc20 inhbitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J.Cell Biol. 190 89 PMID: 20624902


If you know of a relevant reference for AZ 3146, please let us know.

按产品操作查看相关产品

查看全部 Monopolar Spindle 1 Kinase Inhibitors

关键词: AZ 3146, AZ 3146 supplier, AZ, astrazeneca, Mps1, monopolar, spindle, selective, potent, inhibitors, inhibits, SAC, assembly, checkpoint, control, TTK, dual-specificity, protein, kinases, kinetochores, CENP-E, centromere, E, AZ3146, Checkpoint, Control, Kinases, Monopolar, Spindle, 1, Kinase, 3994, Tocris Bioscience

13 篇 AZ 3146 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AZ 3146 的部分引用包括:

Haase et al (2017) Distinct Roles of the Chromosomal Passenger Complex in the Detection of and Response to Errors in Kinetochore-Microtubule Attachment. Dev Cell 42 640 PMID: 28950102

Joana C et al (2020) Small-molecule inhibition of aging-associated chromosomal instability delays cellular senescence. EMBO Rep 21 e49248 PMID: 32134180

Shabaz et al (2020) Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit. Elife 9 PMID: 32869743

Drpic et al (2018) Chromosome Segregation Is Biased by Kinetochore Size. Curr Biol 28 1344 PMID: 29706521


您是否知道使用了 Tocris AZ 3146 的优秀论文? 请告知我们.

AZ 3146 的评论

目前没有该产品的评论。 Be the first to review AZ 3146 and earn rewards!

Have you used AZ 3146?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.