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AZD 3147

Cat. No. 5615 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5615 has been discontinued.

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说明： Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable
化学名： N-[4-[4-[1-(Cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)thiourea
纯度： ≥95% (HPLC)
说明书
引用文献
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文献 (2)
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生物活性 技术数据 说明书 参考文献

生物活性 for AZD 3147

AZD 3147 is a potent and selective dual mTORC1 and 2 inhibitor (IC50 = 1.5 nM). Exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. Orally bioavailable.

化合物库 for AZD 3147

AZD 3147 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AZD 3147

分子量 517.66
公式 C24H31N5O4S2
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 1101810-02-9
PubChem ID 25168990
InChI Key JWGVUDPAMQEIJU-INIZCTEOSA-N
Smiles OCCNC(NC(C=C1)=CC=C1C2=NC(C3(CC3)S(C4CC4)(=O)=O)=CC(N5[C@@H](C)COCC5)=N2)=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for AZD 3147

参考文献是支持产品生物活性的出版物。

Pike et al (2015) Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J.Med.Chem. 58 2326 PMID: 25643210

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关键词: AZD 3147, AZD 3147 supplier, AZD3147, mTORC1, mTORC2, mammalian, mechanistic, target, of, rapamycin, inhibitors, inhibits, potent, selective, orally, bioavailable, mTOR, 5615, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for AZD 3147

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.