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AZD 5582 dihydrochloride

Cat. No. 5141 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Dimeric Smac mimetic; potent IAP inhibitor
化学名： 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide
纯度： ≥97% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZD 5582 dihydrochloride

AZD 5582 dihydrochloride is a dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.

许可信息

Sold with the permission of AstraZeneca UK Ltd

技术数据 for AZD 5582 dihydrochloride

分子量 1088.21
公式 C58H78N8O8.2HCl
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 1883545-51-4
PubChem ID 90489014
InChI Key DAILKFFMJFAUCE-GXSVUDMFSA-N
Smiles CN[C@@H](C)C(N[C@@H]([C@H]1CCCCC1)C(N2[C@H]([C@](N[C@H]3C(C=CC=C5)=C5C[C@H]3OCC#CC#CCO[C@@H]4CC8=C(C=CC=C8)[C@@H]4N[C@@]([C@H](CCC7)N7C([C@H]([C@H]6CCCCC6)NC([C@H](C)NC)=O)=O)=O)=O)CCC2)=O)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZD 5582 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 108.82 100
DMSO 108.82 100

制备储备液 for AZD 5582 dihydrochloride

以下数据基于产品分子量 1088.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 0.92 mL 4.59 mL 9.19 mL
5 mM 0.18 mL 0.92 mL 1.84 mL
10 mM 0.09 mL 0.46 mL 0.92 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

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产品说明书 for AZD 5582 dihydrochloride

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for AZD 5582 dihydrochloride

参考文献是支持产品生物活性的出版物。

Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J.Med.Chem. 56 9897 PMID: 24320998

If you know of a relevant reference for AZD 5582 dihydrochloride, please let us know.

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关键词: AZD 5582 dihydrochloride, AZD 5582 dihydrochloride supplier, AZD5582, dihydrochloride, dimeric, smac, inhibitors, potent, x-linked, cellular, cIAP1, cIAP2, XIAP, IAP, inhibits, apoptosis, protein, anticancer, BIR3, domain, 1258392-53-8, Inhibitor, of, Apoptosis, (IAP), Other, ER, stress/UPR, 5141, Tocris Bioscience

3 篇 AZD 5582 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AZD 5582 dihydrochloride 的部分引用包括：

Ying et al (2022) CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Autophagy 18 726-744 PMID: 34282994

Patrick J et al (2023) A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. PLoS Pathog 19 e1011101 PMID: 36706161

Zinecker et al (2017) ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect. Oncotarget 8 106764 PMID: 29290987

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AZD 5582 dihydrochloride 的评论

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It worked good.
By Anonymous on 07/12/2020
分析类型： In Vitro
种属： Human
细胞系/组织： colorectal cancer cells

10 µM

PMID: 29290987
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Pathways for AZD 5582 dihydrochloride

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Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.