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Azithromycin

Cat. No. 3771 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation
别名： CP 62993
化学名： 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Azithromycin

Azithromycin is a macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models. Inhibits autophagy. Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for Azithromycin

Azithromycin is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Azithromycin

分子量 748.98
公式 C38H72N2O12
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 83905-01-5
PubChem ID 447043
InChI Key MQTOSJVFKKJCRP-BICOPXKESA-N
Smiles [H][C@@]1(O[C@@H]([C@H](C)[C@@H](O[C@@]3([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@](C)(O)C[C@@H](C)C2)[C@@H](C)C(O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)N2C)=O)O[C@@H](C)[C@H](O)[C@](C)(OC)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Azithromycin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 74.9 100
ethanol 74.9 100

制备储备液 for Azithromycin

以下数据基于产品分子量 748.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.68 mL 13.35 mL
5 mM 0.27 mL 1.34 mL 2.67 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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产品说明书 for Azithromycin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Azithromycin

参考文献是支持产品生物活性的出版物。

Retsema et al (1987) Spectrum and mode of action of azithro. (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms. Antimicrob.Agents Chemother. 31 1939 PMID: 2449865

Girard et al (1987) Pharmacokinetic and in vivo studies with azithro. (CP-62,993), a new macrolide with extended half-life and excellent tissue distribution. Antimicrob.Agents Chemother. 31 1948 PMID: 2830841

Champney and Burdine (1995) Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureas. Antimicrob.Agents Chemother. 39 2141 PMID: 8540733

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

Sandeep and McGregor et al (2020) Energetics based modeling of hydroxychloroquine and azithromycin binding to the SARS-CoV-2 spike (S) protein - ACE2 complex. ChemRxiv - Paper not yet peer reviewed.

If you know of a relevant reference for Azithromycin, please let us know.

按标靶查看相关产品

关键词: Azithromycin, Azithromycin supplier, Macrolides, antibiotics, Inhibits, inhibitors, 50S, ribosomal, subunit, formation, elongation, transpeptidation, gram, positive, negative, CP62993, Pfizer, CP, 62993, DNA,, RNA, and, Protein, Synthesis, Antibiotics, Autophagy, COVID-19, Coronavirus, 3771, Tocris Bioscience

3 篇 Azithromycin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Azithromycin 的部分引用包括：

Broad and Sanger (2013) The antibiotic azithro. is a motilin receptor agonist in human stomach: comparison with erythro. Br J Pharmacol 168 1859 PMID: 23190027

Palmer et al (2018) Nonoptimal Gene Expression Creates Latent Potential for Antibiotic Resistance. Mol Biol Evol 35 2669 PMID: 30169679

Groote et al (2018) Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent. Front Microbiol 9 2231 PMID: 30294313

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Azithromycin 的评论

平均评分: 5 (Based on 1 Review.)

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Human tissue pharmacology.
By John Broad on 01/05/2018
分析类型： In Vitro
种属： Human

Human EFS GI smooth muscle assay

Use at 100-300uM for efficacy as motilin agonist

review image

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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