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Submit ReviewAZM 475271
说明： Src tyrosine kinase inhibitor
化学名： N-(2-Chloro-5-methoxyphenyl)-6-methoxy
纯度： ≥99% (HPLC)
生物活性 for AZM 475271
AZM 475271 is a src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).
许可信息
Sold with the permission of AstraZeneca UK Ltd.
化合物库 for AZM 475271
AZM 475271 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for AZM 475271
| 分子量 | 442.94 |
| 公式 | C23H27ClN4O3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 476159-98-5 |
| PubChem ID | 5330175 |
| InChI Key | WPOXAFXHRJYEIC-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(OC)C=C1NC3=NC=NC2=CC(OCC4CCN(C)CC4)=C(OC)C=C23 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AZM 475271
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 44.29 | 100 |
制备储备液 for AZM 475271
以下数据基于产品分子量 442.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.29 mL | 22.58 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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产品说明书 for AZM 475271
参考文献 for AZM 475271
参考文献是支持产品生物活性的出版物。
Yezhelyev et al (2004) Inhibition of Src tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin.Cancer Res. 10 8028 PMID: 15585638
Summy et al (2005) AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol.Cancer Ther. 4 1900 PMID: 16373705
If you know of a relevant reference for AZM 475271, please let us know.
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关键词: AZM 475271, AZM 475271 supplier, AZM475271, inhibits, Src, family, tyrosine, kinase, inhibitors, astrazeneca, Kinases, 3963, Tocris Bioscience
4 篇 AZM 475271 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AZM 475271 的部分引用包括：
Thakur et al (2015) Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep 5 10194 PMID: 25973915
Gautam et al (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer 15 75 PMID: 27871326
Wang et al (2016) Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2. Br J Pharmacol 173 3342 PMID: 27638545
Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443 PMID: 23241962
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