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Azoramide

Cat. No. 5796 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5796 has been discontinued.

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说明： Unfolded protein response (UPR) modulator
化学名： N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for Azoramide

Modulator of unfolded protein response (UPR). Protects cells from ER stress by improving ER protein folding and activating ER chaperone capacity. Also improves ER calcium retention. Improves liver ER function, glucose homeostasis and glucose-stimulated insulin secretion in mouse obesity models. Orally bioavailable.

技术数据 for Azoramide

分子量 308.83
公式 C15H17ClN2OS
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 932986-18-0
PubChem ID 7518316
InChI Key VYBFWKKCWTXCQX-UHFFFAOYSA-N
Smiles ClC1=CC=C(C2=NC(CCNC(CCC)=O)=CS2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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参考文献 for Azoramide

参考文献是支持产品生物活性的出版物。

Fu et al (2015) Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci.Transl.Med. 7 292ra98 PMID: 26084805

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关键词: Azoramide, Azoramide supplier, unfolded, protein, response, UPR, endoplasmic, reticulum, stress, ER, antidiabetic, orally, bioavailable, folding, modulators, PERK, Other, stress/UPR, 5796, Tocris Bioscience

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