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Submit ReviewBAPTA is a selective calcium chelator.
分子量 | 476.44 |
公式 | C22H24N2O10 |
储存 | Store at +4°C |
纯度 | ≥95% (HPLC) |
CAS Number | 85233-19-8 |
PubChem ID | 104751 |
InChI Key | FTEDXVNDVHYDQW-UHFFFAOYSA-N |
Smiles | OC(=O)CN(CC(O)=O)C1=CC=CC=C1OCCOC1=C(C=CC=C1)N(CC(O)=O)CC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
sodium bicarbonate (0.3N) | 4.76 | 10 |
以下数据基于产品分子量 476.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.99 mL | 104.95 mL | 209.89 mL |
0.5 mM | 4.2 mL | 20.99 mL | 41.98 mL |
1 mM | 2.1 mL | 10.49 mL | 20.99 mL |
5 mM | 0.42 mL | 2.1 mL | 4.2 mL |
参考文献是支持产品生物活性的出版物。
Hardie (2005) Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium 38 547 PMID: 16140375
If you know of a relevant reference for BAPTA, please let us know.
关键词: BAPTA, BAPTA supplier, Selective, Ca2+, chelator, calcium, Signaling, Signalling, Agents, General, Reagents, Calcium, Biochemicals, and, Molecular, Biology, 2786, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 BAPTA 的部分引用包括:
Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Cell Death Dis 7 62 PMID: 25071439
Arozarena et al (2011) Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell 19 45 PMID: 21215707
Florea et al (2017) Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget 8 22876 PMID: 28206967
Pick et al (2017) mGluR long-term depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum. EMBO J 36 232 PMID: 27856517
Leroy et al (2017) Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron 95 1089 PMID: 28823730
Alpert and Alford (2013) Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons. PLoS One 8 e63154 PMID: 23646190
Reneau et al (2009) Phorbol 12-myristate 13-acetate potentiation of N-MthD.-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by protein kinase C alpha. J Pharmacol Exp Ther 330 641 PMID: 19429793
Kaeser-Woo et al (2013) Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP. J Neurosci 33 9769 PMID: 23739973
Navarrete et al (2012) Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS Biol 10 e1001259 PMID: 22347811
Chefetz et al (2019) A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep 26 3061 PMID: 30865894
Cilz et al (2014) DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels. Cereb Cortex 24 3195 PMID: 23843440
Carlsen and Perrier (2014) Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits 8 60 PMID: 24926236
Andrade-Talavera et al (2016) Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus. Cereb Cortex 26 3637 PMID: 27282393
Birnbaum et al (2015) Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. PLoS One 6 e1791 PMID: 26086964
Vemana et al (2015) A critical role for the transient receptor potential channel type 6 in human platelet activation. Cell Commun Signal 10 e0125764 PMID: 25928636
Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545 PMID: 25751534
Tabatadze et al (2015) Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci 35 11252 PMID: 26269634
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In order to permit remote regulation of Ca2+, a selective BAPTA-type synthetic receptor / host was integrated with a photoswitchable azobenzene motif, which upon photoirradiation would enhance (or diminish) the capacity to bind calcium upon acting on the conformation of the adjacent binding site, rendering it a stronger or weaker binder.