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BAY 091

Cat. No. 7673 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective PIP4K2A inhibitor
化学名： (R)-2-((3-Cyano-2-(2'-fluoro-3'-methyl-[1,1'-biphenyl]-4-yl)-1,7-naphthyridin-4-yl)amino)butanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAY 091

BAY 091 is a potent and selective, ATP-dependent, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) inhibitor (IC50 values are 1.3 nM, 8.5 nM and 16.4 nM with 10 μM ATP, or in an HTRF assay with 10 μM and 2 mM ATP, respectively).

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 091 probe summary on the SGC website.

技术数据 for BAY 091

分子量 440.48
公式 C26H21FN4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2922280-34-8
PubChem ID 155884467
InChI Key DVIVLYHDLNAXAT-OAQYLSRUSA-N
Smiles CC[C@H](C(O)=O)NC1=C(C(C2=CC=C(C3=C(C(C)=CC=C3)F)C=C2)=NC4=C1C=CN=C4)C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 091

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.02 50 温和加热

制备储备液 for BAY 091

以下数据基于产品分子量 440.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.54 mL 22.7 mL 45.41 mL
2.5 mM 0.91 mL 4.54 mL 9.08 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
25 mM 0.09 mL 0.45 mL 0.91 mL

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Reconstitution Calculator

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参考文献 for BAY 091

参考文献是支持产品生物活性的出版物。

Wortmann et al (2021) Discovery and characterization of the potent and highly selective 1,7-naphthyridine-based inhibitors BAY-091 and BAY-297 of the kinase PIP4K2A. J.Med.Chem. 64 15883 PMID: 34699202

If you know of a relevant reference for BAY 091, please let us know.

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关键词: BAY 091, BAY 091 supplier, BAY091, PIP4K2A, kinase, inhibitor, inhibits, inhibitors, inhibit, potent, selective, probe, phosphatidylinositol-5-phosphate, 4-kinase, Other, Kinases, 7673, Tocris Bioscience

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