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Betulinic acid

Cat. No. 3906 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
化学名： (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid
说明书
引用文献 (2)
评论
文献 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Betulinic acid

Betulinic acid is a natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC50 = 1.04 μM, efficacy 83%). Betulinic acid suppresses areobic glycolysis by regulating the Cav-1/NF-κB/c-Myc pathway in and inhibits growth in breast cancer cells.

技术数据 for Betulinic acid

分子量 456.7
公式 C30H48O3
储存 Store at +4°C
CAS Number 472-15-1
PubChem ID 64971
InChI Key QGJZLNKBHJESQX-FZFNOLFKSA-N
Smiles O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@@]([H])2CC[C@@]4([H])[C@](C)3CC[C@]5([C@](O)=O)[C@@]([H])4[C@H]([C@@](C)=C)CC5)([H])C(C)1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Betulinic acid

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.84 50

制备储备液 for Betulinic acid

以下数据基于产品分子量 456.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.38 mL 21.9 mL 43.79 mL
2.5 mM 0.88 mL 4.38 mL 8.76 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
25 mM 0.09 mL 0.44 mL 0.88 mL

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参考文献 for Betulinic acid

参考文献是支持产品生物活性的出版物。

Kashiwada et al (1996) Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents. J.Med.Chem. 39 1016 PMID: 8676334

Fulda (2008) Betulinic acid for cancer treatment and prevention. Int.J.Mol.Sci. 9 1096 PMID: 19325847

Genet et al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178 PMID: 19911773

Jiao et al (2019) Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-?B/c-Myc pathway. Biochem.Pharmacol. 161 149 PMID: 30684465

If you know of a relevant reference for Betulinic acid, please let us know.

按标靶查看相关产品

关键词: Betulinic acid, Betulinic acid supplier, antitumor, anti-HIV, NFkappaB, NF-kB, NFκB, TGR5, receptors, activators, activates, apoptosis, inducers, partial, agonists, agonism, Cav-1, c-Myc, Apoptosis, Inducers, NF-kB/IkB, GPBA, Receptors, 3906, Tocris Bioscience

2 篇 Betulinic acid 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Betulinic acid 的部分引用包括：

Qing et al (2022) MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization. Sci Rep 12 4183 PMID: 35264604

Inoue et al (2012) Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Neurotox Res 303 G810 PMID: 22821947

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该领域的文献

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Betulinic acid

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.