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Submit ReviewBiotin-NAD+
说明： Biotinylated-NAD+; substrate for ADP-ribosylation
化学名： β-Nicotinamide-N6-[2-[[6-[biotinyl]amino]hexyl]amino]-2-oxoethyl]adenine dinucleotide
生物活性 for Biotin-NAD+
Biotin-NAD+ is a provides a convenient non-isotopic alternative to radiolabeled NAD+ for determination of IC50 values for candidate PARP inhibitors and studies requiring this substrate. Biotinylated-NAD+ allows an indirect measure of PARP activity when biotin incorporation is detected using a conjugated-streptavidin detection system. Acts as a substrate for ADP-ribosylation. Can be used to label and purify biotinyl-ADP ribosylated proteins.
This product is a replacement for R&D Systems product 4670-500-01.
131 μg is supplied as 500 μl of a 0.25 mM solution in water.
技术数据 for Biotin-NAD+
| 分子量 | 1045.95 |
| 公式 | C39H57N11O17P2S |
| 储存 | Store at -80°C |
| CAS Number | 146385-37-7 |
| InChI Key | MIIADCCJYSONEI-RNWYXDGLSA-N |
| Smiles | [H][C@]12CS[C@H]([C@]1(NC(N2)=O)[H])CCCCC(NCCCCCCNC(CNC3=C(N=CN4[C@@H]5O[C@@H]([C@H]([C@H]5O)O)COP(O)(OP(OC[C@H]6O[C@@H]([N+]7=CC=CC(C(N)=O)=C7)[C@H](O)[C@@H]6O)([O-])=O)=O)C4=NC=N3)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Biotin-NAD+
| 溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 0.25mM) |
产品说明书 for Biotin-NAD+
参考文献 for Biotin-NAD+
参考文献是支持产品生物活性的出版物。
Zhang et al (1993) Purification of a nitric oxide-stimulated ADP-ribosylated protein using biotinylated beta-nicotinamide adenine dinucleotide. Biochemistry 32 2228 PMID: 8443164
Yang et al (2017) Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9 Mol. Cell 66 613 PMID: 28525742
Schuster et al (2017) The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells. Sci.Rep. 7 613 PMID: 28377614
Yang (2013) Antitumor activity of a pyrrole-imidazole polyamide. Proc.Natl.Acad.Sci.USA 110 1863 PMID: 23319609
If you know of a relevant reference for Biotin-NAD+, please let us know.
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关键词: Biotin-NAD+, Biotin-NAD+ supplier, 6-Biotin-17-NAD, 6-Biotin-10-NAD, Biotin-NAD+, Biotinylated-NAD, ADP-ribosylation, substrates, PARP, Biochemicals, and, Molecular, Biology, 6573, Tocris Bioscience
1 篇 Biotin-NAD+ 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Biotin-NAD+ 的部分引用包括：
Andrew et al (2022) Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. J Cell Biol 221 PMID: 35157000
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