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BMS 509744

Cat. No. 5009 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5009 has been discontinued.

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说明： Potent and selective ITK inhibitor
化学名： N-[5-[[5-[(4-Acetyl-1-piperazinyl)carbonyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[[(1,2,2-trimethylpropyl)amino]methyl]benzamide
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for BMS 509744

BMS 509744 is a potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitor (IC50 = 19 nM). Displays 200-fold selectivity over Tec family kinases and 55-fold selectivity over other kinases tested. Reduces HIV infection of primary CD4+ T cells and attenuates the establishment of HIV infection in vitro. Reduces T cell proliferation and IL-2 production in vitro. Reduces lung inflammation in a mouse model of ovalbumin-induced allergy/asthma.

化合物库 for BMS 509744

BMS 509744 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BMS 509744

分子量 623.83
公式 C32H41N5O4S2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 439575-02-7
PubChem ID 11467730
InChI Key ZHXNIYGJAOPMSO-UHFFFAOYSA-N
Smiles COC1=CC(C)=C(SC3=CN=C(NC(C4=CC=C(CNC(C)C(C)(C)C)C=C4)=O)S3)C=C1C(N2CCN(C(C)=O)CC2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BMS 509744

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for BMS 509744

参考文献是支持产品生物活性的出版物。

Kutach et al (2010) Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation. Chem Biol Drug Des. 76 154 PMID: 20545945

Das et al (2006) Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg.Med.Chem.Lett. 16 3706 PMID: 16682193

Readinger et al (2008) Selective targeting of ITK blocks multiple steps of HIV replication. Proc.Natl.Acad.Sci.U.S.A. 105 6684 PMID: 18443296

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关键词: BMS 509744, BMS 509744 supplier, BMS509744, lung, inflammation, allergy, asthma, inducible, T, cell, kinase, emt, tsk, HIV, potent, selective, ITK, inhibitors, inhibits, Il2, 5009, Tocris Bioscience

1 篇 BMS 509744 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMS 509744 的部分引用包括：

Mamand et al (2018) Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep 8 14216 PMID: 30242208

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