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BMX-IN-1

Cat. No. 5123 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and irreversible BMX inhibitor
化学名： N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BMX-IN-1

BMX-IN-1 is a potent and irreversible BMX inhibitor (IC50 = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.

许可信息

Sold under license from Dana-Farber Cancer Institute.

External Portal Information for BMX-IN-1

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMX-IN-1 is reviewed on the chemical probes website.

技术数据 for BMX-IN-1

分子量 524.59
公式 C29H24N4O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1431525-23-3
PubChem ID 71576693
InChI Key SFMJNHNUOVADRW-UHFFFAOYSA-N
Smiles CC(C=C5)=C(NC(C=C)=O)C=C5N(C2=C(C=C3)C=NC1=CC=C(C4=CC=C(NS(=O)(C)=O)C=C4)C=C12)C3=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BMX-IN-1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 0.52 1 温和加热

制备储备液 for BMX-IN-1

以下数据基于产品分子量 524.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.01 mM 190.63 mL 953.13 mL 1906.25 mL
0.05 mM 38.13 mL 190.63 mL 381.25 mL
0.1 mM 19.06 mL 95.31 mL 190.63 mL
0.5 mM 3.81 mL 19.06 mL 38.13 mL

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参考文献 for BMX-IN-1

参考文献是支持产品生物活性的出版物。

Liu et al (2013) Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem.Biol. 8 1423 PMID: 23594111

Li et al (2017) BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways. Oncotarget. 8 49238 PMID: 28514765

If you know of a relevant reference for BMX-IN-1, please let us know.

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关键词: BMX-IN-1, BMX-IN-1 supplier, BMX, inhibitors, inhibits, nonreceptor, tyrosine, kinase, potent, irreversible, selective, Other, Kinases, 5123, Tocris Bioscience

1 篇 BMX-IN-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMX-IN-1 的部分引用包括：

Rudolf et al (2021) Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening. Cell Rep 35 109233 PMID: 34133938

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