Bosutinib

Cat. No. 4361 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Dual Src-Abl inhibitor; antiproliferative

别名： SKI-606

化学名： 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile

纯度： ≥99%

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Bosutinib

Bosutinib is a dual inhibitor of Abl and Src kinases (IC₅₀ = 1.2 nM for Src in an enzymatic assay). Displays antiproliferative activity against chronic myelogenous leukemia (CML) cells and decreases the motility and invasion of breast cancer cell lines. Also exhibits potent antiproliferative activity in anchorage-independent, Src-transformed rat fibroblasts (IC₅₀ = 100 nM). Displays selectivity for Src over non-Src family kinases such as growth factor receptor tyrosine kinases.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for Bosutinib

Bosutinib is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Bosutinib

分子量	530.45
公式	C₂₆H₂₉Cl₂N₅O₃
储存	Store at +4°C
纯度	≥99%
CAS Number	380843-75-4
PubChem ID	5328940
InChI Key	UBPYILGKFZZVDX-UHFFFAOYSA-N
Smiles	ClC1=CC(Cl)=C(OC)C=C1NC3=C(C#N)C=NC2=CC(OCCCN4CCN(C)CC4)=C(OC)C=C23

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bosutinib

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	53.05	100
	ethanol	13.26	25

制备储备液 for Bosutinib

以下数据基于产品分子量 530.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.89 mL	9.43 mL	18.85 mL
5 mM	0.38 mL	1.89 mL	3.77 mL
10 mM	0.19 mL	0.94 mL	1.89 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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产品说明书 for Bosutinib

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Bosutinib

参考文献是支持产品生物活性的出版物。

Boschelli et al (2001) Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J.Med.Chem. 44 3965 PMID: 11689083

Golas et al (2003) SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res. 63 375 PMID: 12543790

Golas et al (2005) SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res. 65 5358 PMID: 15958584

Vultur et al (2008) SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol.Cancer.Ther. 7 1185 PMID: 18483306

If you know of a relevant reference for Bosutinib, please let us know.

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