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BTD S-sulfenic acid probe

Cat. No. 8059 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Chemoproteomic reagent for targeting S-sulfenic acids on SulfenQ platform, alkyne handle for click chemistry
化学名： 1-(4-Pentyn-1-yl)-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BTD S-sulfenic acid probe

BTD S-sulfenic acid probe is a nucleophilic fragment that can selectively modify sulfenic acid residues in proteins, and can be used as a tool to identify ligandable S-sulfenation sites. Covalently modifies oxidized cysteines on proteins. Quantitatively labels hyper-reactive sulfenic acids at low BTD concentrations, less reactive sites exhibit concentration-dependent increases in probe labeling. Incorporates an alkyne handle for click chemistry and chemoproteomic profiling.

技术数据 for BTD S-sulfenic acid probe

分子量 263.31
公式 C13H13NO3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2095485-22-4
PubChem ID 155551901
InChI Key GSSKUKMXWRNMFK-UHFFFAOYSA-N
Smiles O=C1C2=C(N(S(=O)(C1)=O)CCCC#C)C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BTD S-sulfenic acid probe

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.33 100
ethanol 5.27 20

制备储备液 for BTD S-sulfenic acid probe

以下数据基于产品分子量 263.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.8 mL 18.99 mL 37.98 mL
5 mM 0.76 mL 3.8 mL 7.6 mL
10 mM 0.38 mL 1.9 mL 3.8 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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产品说明书 for BTD S-sulfenic acid probe

分析证书/产品说明书
化学品安全技术说明书

参考文献 for BTD S-sulfenic acid probe

参考文献是支持产品生物活性的出版物。

Fu et al (2023) Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat.Chem.Biol. 19 1309 PMID: 37248412

Gupta et al (2017) Diverse redoxome reactivity profiles of carbon nucleophiles. J.Am.Chem.Soc. 139 5588 PMID: 28355876

If you know of a relevant reference for BTD S-sulfenic acid probe, please let us know.

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关键词: BTD S-sulfenic acid probe, BTD S-sulfenic acid probe supplier, BTD, sulfenic, acid, probe, sulfenation, cysteine, alkyne, handle, click, chemistry, s-sulfenation, Biochemicals, and, Molecular, Biology, 8059, Tocris Bioscience

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