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C-1

Cat. No. 0543 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0543 has been discontinued.

View all Broad Spectrum Protein Kinase Inhibitors products.
说明： Inhibits PKG, PKA and PKC
别名： HA 100
化学名： 1-(5-Isoquinolinesulfonyl)piperazine
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for C-1

C-1 is a protein kinase inhibitor. Inhibits PKG, PKA and PKC (IC50 values are 4, 8 and 12 μM, respectively). Widely used as a ROCK inhibitor. Increases efficiency of human fibroblast reprogramming with PD 0325901 (Cat.No 4192), CHIR 99021 (Cat.No 4432), A 83-01 (Cat.No 2939) and hLIF. Improves survival of human pluripotent stem cells in culture.

技术数据 for C-1

分子量 277.34
公式 C13H15N3O2S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 84468-24-6
PubChem ID 3545
InChI Key UPTYCYWTFGTCCG-UHFFFAOYSA-N
Smiles O=S(=O)(N1CCNCC1)C1=C2C=CN=CC2=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for C-1

参考文献是支持产品生物活性的出版物。

Gerard et al (1986) Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidation metabolism by various agonists. J.Clin.Invest. 77 61 PMID: 3003155

Yu et al (2011) Efficient feeder-free episomal reprogramming with small molecules. PLoS.One. 6 e17557 PMID: 21390254

Chen et al (2011) Chemically defined conditions for human iPSC derivation and culture. Nat.Methods 8 424 PMID: 21478862

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关键词: C-1, C-1 supplier, Protein, kinase, C, A, G, inhibitors, inhibits, PKC, Kinases, vasodilator, HA-100, PKG, PKA, HA, 100, Broad, Spectrum, Kinase, Inhibitors, Stem, Cell, Reprogramming, 0543, Tocris Bioscience

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