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C16

Cat. No. 5382 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PKR inhibitor
化学名： 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for C16

C16 is a PKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block in vitro. Decreases Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.

技术数据 for C16

分子量 268.29
公式 C13H8N4OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 608512-97-6
PubChem ID 6490494
InChI Key VFBGXTUGODTSPK-BAQGIRSFSA-N
Smiles O=C2NC1=CC=C4C(SC=N4)=C1/C2=C/C3=CNC=N3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for C16

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 13.41 50
ethanol 5.37 20

制备储备液 for C16

以下数据基于产品分子量 268.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 7.45 mL 37.27 mL 74.55 mL
2.5 mM 1.49 mL 7.45 mL 14.91 mL
5 mM 0.75 mL 3.73 mL 7.45 mL
25 mM 0.15 mL 0.75 mL 1.49 mL

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参考文献 for C16

参考文献是支持产品生物活性的出版物。

Jammi et al (2003) Small molecule inhibitors of the RNA-dependent protein kinase. Biochem.Biophys.Res.Comm. 308 50 PMID: 12890478

Ingrand et al (2007) The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. FEBS Lett. 581 4473 PMID: 17761171

Couturier et al (2011) Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures. J.Neuroinflammation 8 PMID: 21699726

Tronel et al (2014) The specific PKR inhibitor C16 prevents apoptosis and IL-1 beta production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem.Int. 64 73 PMID: 24211709

If you know of a relevant reference for C16, please let us know.

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关键词: C16, C16 supplier, Double-stranded, RNA-dependent, proteins, kinases, PKR, inhibitors, inhibits, neuroprotective, neuroprotection, neuroinflammation, Other, Kinases, 5382, Tocris Bioscience

3 篇 C16 的引用文献

引用文献是使用了 Tocris 产品的出版物。 C16 的部分引用包括：

Jiang and Steinle (2019) Epac1 inhibits PKR to reduce NLRP3 inflammasome proteins in retinal endothelial cells. J Inflamm Res 12 153 PMID: 31354329

Charles et al (2021) Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer. Cell Rep 36 109491 PMID: 34348154

Sean P et al (2021) Activating transcription factor-4 promotes neuronal death induced by Parkinson's disease neurotoxins and α-synuclein aggregates. Cell Death Differ 28 1627-1643 PMID: 33277577

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