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C28

Cat. No. 7546 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent LMTK3 inhibitor
化学名： 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for C28

C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα.

许可信息

Sold with kind permission of the Giamas lab, University of Sussex

技术数据 for C28

分子量 356.31
公式 C18H11F3N4O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2764850-23-7
PubChem ID 138454301
InChI Key SFBZOJORTROAIE-UHFFFAOYSA-N
Smiles FC(F)(OC1=CC(C2=CN=C3C=CC(C4=CC=NC=C4)=NN32)=CC=C1)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for C28

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.82 50
ethanol 7.13 20

制备储备液 for C28

以下数据基于产品分子量 356.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.61 mL 28.07 mL 56.13 mL
2.5 mM 1.12 mL 5.61 mL 11.23 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
25 mM 0.11 mL 0.56 mL 1.12 mL

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参考文献 for C28

参考文献是支持产品生物活性的出版物。

Ditsiou et al (2020) The structure-function relationship of oncogenic LMTK3. Sci.Adv. 6 eabc3099 PMID: 33188023

If you know of a relevant reference for C28, please let us know.

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关键词: C28, C28 supplier, LMTK3, lemur, tyrosine, kinase, inhibitors, inhibits, potent, kinases, tumor, apoptosis, ER, breast, cancer, hsp90, CLK, DYRK1alpha, Other, Kinases, (Cdc2-like, kinases), DYRK, IRAK, 7546, Tocris Bioscience

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