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CC 0651

Cat. No. 4503 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4503 has been discontinued.

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说明： Allosteric inhibitor of hCdc34
化学名： (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for CC 0651

CC 0651 is an allosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1 (IC50 = 1.72 μM). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.

技术数据 for CC 0651

分子量 442.29
公式 C20H21Cl2NO6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1319207-44-7
PubChem ID 53239927
InChI Key NTCBTNCWNRCBGX-YTQUADARSA-N
Smiles ClC1=CC(Cl)=CC(C2=CC=C(C[C@H](NC(COC)=O)[C@@H]([C@H](C(O)=O)O)O)C=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for CC 0651

参考文献是支持产品生物活性的出版物。

Ceccarelli et al (2011) An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell 145 1075 PMID: 21683433

Huang et al (2014) E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nat.Chem.Biol. 10 156 PMID: 24316736

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关键词: CC 0651, CC 0651 supplier, CC0651, allosteric, inhibitors, inhibits, hCDC34, ubiquitination, selective, ubl, E2, conjugating, enzymes, Ubiquitin/Ubl, Conjugating, Enzymes, Post-translational, Modifications, 4503, Tocris Bioscience

1 篇 CC 0651 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CC 0651 的部分引用包括：

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788

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