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Submit ReviewCCT 241533 dihydrochloride
说明： Potent Chk2 inhibitor
化学名： (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for CCT 241533 dihydrochloride
CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.
许可信息
Sold under license from Cancer Research Technology Ltd (Ximbio).
External Portal Information for CCT 241533 dihydrochloride
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CCT 241533 is reviewed on the chemical probes website.
化合物库 for CCT 241533 dihydrochloride
CCT 241533 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
技术数据 for CCT 241533 dihydrochloride
| 分子量 | 515.41 |
| 公式 | C23H27FN4O4.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1962925-28-5 |
| PubChem ID | 49867844 |
| InChI Key | IXTQNANZDPZION-GSOOIIRJSA-N |
| Smiles | FC1=CC(C3=NC2=CC(OC)=C(OC)C=C2C(N[C@H]4[C@H]([C@](C)(O)C)CNC4)=N3)=C(O)C=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CCT 241533 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 5.15 | 10 温和加热 | |
| DMSO | 51.54 | 100 |
制备储备液 for CCT 241533 dihydrochloride
以下数据基于产品分子量 515.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.94 mL | 9.7 mL | 19.4 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.88 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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产品说明书 for CCT 241533 dihydrochloride
参考文献 for CCT 241533 dihydrochloride
参考文献是支持产品生物活性的出版物。
Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID: 21186793
If you know of a relevant reference for CCT 241533 dihydrochloride, please let us know.
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关键词: CCT 241533 dihydrochloride, CCT 241533 dihydrochloride supplier, checkpoint, kinase, 2, CHK, inhibitors, inhibits, radioprotectant, potent, selective, Checkpoint, Kinases, Control, 4968, Tocris Bioscience
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.