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CCT 241533 dihydrochloride

Cat. No. 4968 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4968 has been discontinued.

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说明： Potent Chk2 inhibitor
化学名： (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for CCT 241533 dihydrochloride

CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

许可信息

Sold under license from Cancer Research Technology Ltd (Ximbio).

External Portal Information for CCT 241533 dihydrochloride

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CCT 241533 is reviewed on the chemical probes website.

化合物库 for CCT 241533 dihydrochloride

CCT 241533 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CCT 241533 dihydrochloride

分子量 515.41
公式 C23H27FN4O4.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1962925-28-5
PubChem ID 49867844
InChI Key IXTQNANZDPZION-GSOOIIRJSA-N
Smiles FC1=CC(C3=NC2=CC(OC)=C(OC)C=C2C(N[C@H]4[C@H]([C@](C)(O)C)CNC4)=N3)=C(O)C=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CCT 241533 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for CCT 241533 dihydrochloride

参考文献是支持产品生物活性的出版物。

Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID: 21186793

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关键词: CCT 241533 dihydrochloride, CCT 241533 dihydrochloride supplier, checkpoint, kinase, 2, CHK, inhibitors, inhibits, radioprotectant, potent, selective, Checkpoint, Kinases, Control, 4968, Tocris Bioscience

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Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.