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Submit ReviewCentrinone B
说明： High affinity and selective PLK4 inhibitor
别名： LCR 323
化学名： 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine
纯度： ≥98% (HPLC)
生物活性 for Centrinone B
Centrinone B is a high affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.
许可信息
Sold with the permission of the Ludwig Institute for Cancer Research Ltd
技术数据 for Centrinone B
| 分子量 | 631.67 |
| 公式 | C27H27F2N7O5S2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1798871-31-4 |
| PubChem ID | 118704753 |
| InChI Key | UPZNTUYHCRQOIQ-UHFFFAOYSA-N |
| Smiles | FC1=C([N+]([O-])=O)C=CC=C1CS(C2=CC=C(SC3=NC(N4CCCCC4)=C(OC)C(NC5=NNC(C)=C5)=N3)C(F)=C2)(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Centrinone B
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 31.58 | 50 |
制备储备液 for Centrinone B
以下数据基于产品分子量 631.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.17 mL | 15.83 mL | 31.66 mL |
| 2.5 mM | 0.63 mL | 3.17 mL | 6.33 mL |
| 5 mM | 0.32 mL | 1.58 mL | 3.17 mL |
| 25 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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产品说明书 for Centrinone B
参考文献 for Centrinone B
参考文献是支持产品生物活性的出版物。
Wong et al (2015) Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science 348 1155 PMID: 25931445
If you know of a relevant reference for Centrinone B, please let us know.
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关键词: Centrinone B, Centrinone B supplier, LCR323, high, affinity, selective, PLK4, inhibitors, inhibits, centriole, centrosome, LCR, 323, Polo-like, Kinase, Mitosis, 5690, Tocris Bioscience
8 篇 Centrinone B 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Centrinone B 的部分引用包括：
Kazazian et al (2017) Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton. Cancer Res 77 434 PMID: 27872092
Anna et al (2021) Centriole and Golgi microtubule nucleation are dispensable for the migration of human neutrophil-like cells. Mol Biol Cell 32 1545-1556 PMID: 34191538
Dong et al (2020) Prolonged mitosis results in structurally aberrant and over-elongated centrioles. J Cell Biol 219 PMID: 32271878
Minji et al (2020) FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity. Commun Biol 3 448 PMID: 32807875
Mues et al (2019) High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep 27 631 PMID: 30970263
Chen et al (2017) Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles. Nat Commun 8 247 PMID: 28811500
Péter et al (2022) Centrosome function is critical during terminal erythroid differentiation. EMBO J 41 e108739 PMID: 35678476
Carol J et al (2022) Investigating the mechanisms of peritoneal metastasis in gastric adenocarcinoma using a novel ex vivo peritoneal explant model. Sci Rep 12 11499 PMID: 35798764
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Centrinone B 的评论
平均评分: 5 (Based on 1 Review.)
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T-ALL Network and Pharmacological Validation of Synthetic Lethal Screen.
By
Anonymous on 03/26/2020
分析类型： In Vitro
种属： Human
细胞系/组织： T cell line
100nM
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