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说明： CHIP/STUB1 E3 ligase inhibitor
纯度： ≥95% (HPLC)
生物活性 for CHIPOpt
CHIPOpt is a CHIP/STUB1 E3 ligase inhibitor. In vitro, CHIPOpt decreases phosphorylated tau ubiquitination, with little effect on unmodified tau. In Thioflavin T assays, CHIPOpt inhibits the ability of CHIP to suppress phosphorylated tau aggregation. FITC-CHIPOpt (Cat. No. 8045), a fluorescent CHIPOpt, is also available.
技术数据 for CHIPOpt
| 分子量 | 757.84 |
| 公式 | C39H47N7O9 |
| 序列 |
LWWPD (Modification: Leu-1 = N-terminal Ac) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| InChI Key | NAUYSEKQVONAJC-ZTTXAYQISA-N |
| Smiles | O=C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N5[C@@H](CCC5)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CHIPOpt
| 溶解性 | Soluble to 2 mg/ml in 0.01M PBS |
产品说明书 for CHIPOpt
参考文献 for CHIPOpt
参考文献是支持产品生物活性的出版物。
Nadel et al (2023) The E3 ubiquitin ligase, CHIP/STUB1, inhibits aggregation of phosphorylated proteoforms of microtubule-associated protein tau (MAPT). J.Mol.Biol. 435 168026 PMID: 37330289
Ravalin et al (2019) Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat.Chem.Biol. 15 786 PMID: 31320752
If you know of a relevant reference for CHIPOpt, please let us know.
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关键词: CHIPOpt, CHIPOpt supplier, CHIPOpt, ubiquitin, ligase, inhibitor, inhibitors, inhibit, ligases, ubiquitination, in, vitro, phosphorylated, tau, aggregation, Ubiquitin, E3, Ligases, 8044, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia