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Submit ReviewCHR 6494 trifluoroacetate
说明： Potent and selective haspin inhibitor
化学名： 3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate
纯度： ≥98% (HPLC)
生物活性 for CHR 6494 trifluoroacetate
CHR 6494 trifluoroacetate is a potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.
化合物库 for CHR 6494 trifluoroacetate
CHR 6494 trifluoroacetate is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
技术数据 for CHR 6494 trifluoroacetate
| 分子量 | 406.36 |
| 公式 | C16H16N6.CF3CO2H |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1458630-17-5 |
| PubChem ID | 91691123 |
| InChI Key | ILWYDZNXJQESDI-UHFFFAOYSA-N |
| Smiles | CCCNC2=NN1C(C3=CC(C=NN4)=C4C=C3)=CN=C1C=C2.OC(C(F)(F)F)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CHR 6494 trifluoroacetate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 40.64 | 100 |
制备储备液 for CHR 6494 trifluoroacetate
以下数据基于产品分子量 406.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.3 mL | 24.61 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.92 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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产品说明书 for CHR 6494 trifluoroacetate
参考文献 for CHR 6494 trifluoroacetate
参考文献是支持产品生物活性的出版物。
Huertas et al (2012) Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 31 1408 PMID: 21804608
If you know of a relevant reference for CHR 6494 trifluoroacetate, please let us know.
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关键词: CHR 6494 trifluoroacetate, CHR 6494 trifluoroacetate supplier, CHR6494, trifluoroacetate, potent, selective, haspin, kinases, inhibitors, inhibits, cell, cycle, arrest, proliferation, apoptosis, GSG2, Haspin, 5326, Tocris Bioscience
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.