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Submit Reviewcis-6-Hydroxynorketamine hydrochloride
说明： Enhances AMPA currents: antidepressant
化学名： cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
纯度： ≥98% (HPLC)
生物活性 for cis-6-Hydroxynorketamine hydrochloride
cis-6-Hydroxynorketamine hydrochloride is a metabolite of ketamine. Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo.
2S,6S-enantiomer and 2R,6R-enantiomer also available.
技术数据 for cis-6-Hydroxynorketamine hydrochloride
| 分子量 | 276.16 |
| 公式 | C12H14ClNO2.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2319601-04-0 |
| PubChem ID | 121513910 |
| InChI Key | ZQJVHBJDLMIKJK-MHDYBILJSA-N |
| Smiles | ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.ClC3=C([C@]4(N)C([C@@H](O)CCC4)=O)C=CC=C3.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for cis-6-Hydroxynorketamine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 27.62 | 100 | |
| DMSO | 27.62 | 100 |
制备储备液 for cis-6-Hydroxynorketamine hydrochloride
以下数据基于产品分子量 276.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.62 mL | 18.11 mL | 36.21 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 10 mM | 0.36 mL | 1.81 mL | 3.62 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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产品说明书 for cis-6-Hydroxynorketamine hydrochloride
参考文献 for cis-6-Hydroxynorketamine hydrochloride
参考文献是支持产品生物活性的出版物。
Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 533 481 PMID: 27144355
Leung and Baillie (1986) Comparative pharmacology in the rat of KA and its two principal metabolites, norKA and (Z)-6-hydroxynorKA. J.Med.Chem. 29 2396 PMID: 3783598
If you know of a relevant reference for cis-6-Hydroxynorketamine hydrochloride, please let us know.
关键词: cis-6-Hydroxynorketamine hydrochloride, cis-6-Hydroxynorketamine hydrochloride supplier, ketamine, metabolite, antidepressant, depression, AMPA, HNK, Receptors, Ketamine, and, Metabolites, 5982, Tocris Bioscience
1 篇 cis-6-Hydroxynorketamine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 cis-6-Hydroxynorketamine hydrochloride 的部分引用包括：
Hans-Georg et al (2019) The novel antidepressant ketamine enhances dentate gyrus proliferation with no effects on synaptic plasticity or hippocampal function in depressive-like rats. Acta Physiol (Oxf) 225 e13211 PMID: 30347138
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