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Submit ReviewKetamine hydrochloride
Description: Non-competitive NMDA receptor antagonist
Chemical Name: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Ketamine hydrochloride
Ketamine hydrochloride is a non-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for GluN1/GluN2A (formally NR1 and NR2A, respectively) and GluN1/GluN2B (formally NR1 and NR2B, respectively) subunit combinations respectively). Dissociative anesthetic.
S-enantiomer and Active metabolite also available.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions. .
Technical Data for Ketamine hydrochloride
| M. Wt | 274.19 |
| Formula | C13H16ClNO.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1867-66-9 |
| PubChem ID | 15851 |
| InChI Key | VCMGMSHEPQENPE-UHFFFAOYSA-N |
| Smiles | O=C1C(C2=CC=CC=C2Cl)(NC)CCCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ketamine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 27.42 | 100 |
Preparing Stock Solutions for Ketamine hydrochloride
The following data is based on the product molecular weight 274.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.65 mL | 18.24 mL | 36.47 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.29 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.65 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
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Product Datasheets for Ketamine hydrochloride
References for Ketamine hydrochloride
References are publications that support the biological activity of the product.
Anis et al (1983) The dissociative anaesthetics, KA and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 79 565 PMID: 6317114
Pallares et al (1995) Effects of KA, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats. Physiol.Behav. 57 389 PMID: 7716221
Liu et al (2001) Modulation of NMDA receptor function by KA and magnesium: part I. Anesth.Pharmacol. 92 1173
If you know of a relevant reference for Ketamine hydrochloride, please let us know.
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1 Citation for Ketamine hydrochloride
Citations are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:
Rzeski et al (2001) Glutamate antagonists limit tumor growth. Oncotarget 98 6372 PMID: 11331750
Do you know of a great paper that uses Ketamine hydrochloride from Tocris? Please let us know.
Reviews for Ketamine hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Anaesthetic and antidepressant drug - works well.
By
Luiz Alexandre Magno on 11/11/2022
Assay Type: In Vivo
Species: Mouse
Ketamine hydrochloride from Tocris has been used in my lab as a potent intraperitoneal anaesthetic for general surgery and also as a candidate drug for treating depression. It has worked well so far. The image shows data from mice anesthetized with an intraperitoneal injection of ketamine solution at 80 mg/kg. The drug was diluted in sterile saline.
Ketamine should be mixed with xylazine for anaesthesia.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.