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Compound E

Cat. No. 6476 5 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： γ-secretase inhibitor; induces neuronal differentiation
别名： γ-Secretase Inhibitor XXI
化学名： N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (5)
评论
实验方案 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Compound E

Compound E is a γ-secretase and notch patchway inhibitor. Compound E enhances growth inhibition, differentiation and migration of neuroblastoma cells when used in a combination with DAPT (Cat. No. 2634) and 13-cis RA. In combination with hLIF, CHIR 99021 (Cat. No. 4423) and SB 431542 (Cat. No. 1614), Compound E accelerates the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs. Compound E is active in vitro and in vivo.

For more information about how Compound E may be used, see our protocol: Generation of β cells from hPSCs

技术数据 for Compound E

分子量 490.5
公式 C27H24F2N4O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 209986-17-4
PubChem ID 11306390
InChI Key JNGZXGGOCLZBFB-IVCQMTBJSA-N
Smiles C[C@@H](C(N[C@H]1N=C(C2=CC=CC=C2N(C1=O)C)C3=CC=CC=C3)=O)NC(CC4=CC(F)=CC(F)=C4)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Compound E

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.05 100

制备储备液 for Compound E

以下数据基于产品分子量 490.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.19 mL 20.39 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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产品说明书 for Compound E

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Compound E

参考文献是支持产品生物活性的出版物。

Li et al (2011) Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc.Natl.Acad.Sci.USA 108 8299 PMID: 21525408

Ferrari-Toninelli et al (2010) Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells. Neuro.Oncol. 12 1231 PMID: 20716592

Beher et al (2001) Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J.Biol.Chem. 276 45394 PMID: 11574530

If you know of a relevant reference for Compound E, please let us know.

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关键词: Compound E, Compound E supplier, gamma-secretase, g-secretase, inhibitors, XXI, inhibits, secretases, neuronal, differentiation, neurons, self, renewal, notch, pathway, Gamma, Secretase, Inhibitor, Gamma-Secretase, Neural, Stem, Cells, Organoids, 6476, Tocris Bioscience

5 篇 Compound E 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Compound E 的部分引用包括：

Sheng et al (2018) A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. Nat Commun 9 4047 PMID: 30279449

Zhan et al (2022) Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation. Nat.Med. 28 798 PMID: 35288694

Mustafa et al (2023) A Robust Pipeline for the Multi-Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells. Curr Protoc 3 e641 PMID: 36633423

Mustafa et al (2022) Dynamic 3D Combinatorial Generation of hPSC-Derived Neuromesodermal Organoids With Diverse Regional and Cellular Identities. Curr Protoc 2 e568 PMID: 36264199

Cheng et al (2022) Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis. Neuron 110 992-1008.e11 PMID: 35045337

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Compound E 实验方案

以下实验方案包含使用 Compound E（目录编号 6476）的更多信息。

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