CRT 0105950

Cat. No. 6273 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent LIMK1/2 inhibitor

化学名： 4-[[5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]phenol

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CRT 0105950

CRT 0105950 is a potent LIMK1/2 inhibitor (IC₅₀ values are 0.3 and 1 nM at LIMK 1 and 2, respectively). Disrupts microtubule organization, inhibits cofilin phosphorylation and increases α-tubulin acetylation in vitro.

化合物库 for CRT 0105950

CRT 0105950 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CRT 0105950

分子量	393.89
公式	C₂₁H₁₆ClN₃OS
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1661845-86-8
PubChem ID	117918970
InChI Key	QYDBOFPHPMYWDO-UHFFFAOYSA-N
Smiles	ClC1=C(C2=CN=CC=C2C3=CN=C(NC4=CC=C(O)C=C4)S3)C=CC(C)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CRT 0105950

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	39.39	100
	ethanol	19.69	50

制备储备液 for CRT 0105950

以下数据基于产品分子量 393.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.69 mL	25.39 mL
5 mM	0.51 mL	2.54 mL	5.08 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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产品说明书 for CRT 0105950

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CRT 0105950

参考文献是支持产品生物活性的出版物。

Charles et al (2015) Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties. J.Med.Chem. 58 8309 PMID: 26356364

Mardilovich et al (2015) LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget. 6 38469 PMID: 26540348

If you know of a relevant reference for CRT 0105950, please let us know.

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关键词: CRT 0105950, CRT 0105950 supplier, CRT0105950, LIMK2, LIMK1, inhibitors, inhibits, lim, kinases, antitumour, antitumor, cofilin, microtubules, LIMK, Microtubules, 6273, Tocris Bioscience

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Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.