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说明： Selective inhibitor of PI 3-kinase γ
化学名： 5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide
纯度： ≥98% (HPLC)
生物活性 for CZC 24832
CZC 24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for CZC 24832
| 分子量 | 364.4 |
| 公式 | C15H17FN6O2S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1159824-67-5 |
| PubChem ID | 42623951 |
| InChI Key | RXRZPHQBTHQXSV-UHFFFAOYSA-N |
| Smiles | NC2=NN1C=C(C3=CN=CC(S(NC(C)(C)C)(=O)=O)=C3)C=C(F)C1=N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CZC 24832
参考文献 for CZC 24832
参考文献是支持产品生物活性的出版物。
Bergamini et al (2012) A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nat.Chem.Biol. 8 576 PMID: 22544264
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关键词: CZC 24832, CZC 24832 supplier, CZC24832, PI3K, PI3-K, PI3kinase, phosphoinositide, 3-kinase, kinases, gamma, inhibitors, inhibits, inflammation, PI, 3-Kinase, Inositol, Lipids, 4674, Tocris Bioscience
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