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DCA

Cat. No. 2755 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor
化学名： Sodium dichloroacetate
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DCA

DCA is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo.

技术数据 for DCA

分子量 150.92
公式 C2HCl2NaO2
储存 Desiccate at RT
CAS Number 2156-56-1
PubChem ID 517326
InChI Key LUPNKHXLFSSUGS-UHFFFAOYSA-M
Smiles [Na+].[O-]C(=O)C(Cl)Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DCA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 15.09 100
DMSO 15.09 100

制备储备液 for DCA

以下数据基于产品分子量 150.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 6.63 mL 33.13 mL 66.26 mL
5 mM 1.33 mL 6.63 mL 13.25 mL
10 mM 0.66 mL 3.31 mL 6.63 mL
50 mM 0.13 mL 0.66 mL 1.33 mL

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参考文献 for DCA

参考文献是支持产品生物活性的出版物。

Bowker-kinley et al (1998) Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem.J. 329 191 PMID: 9405293

Bonnet et al (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11 37 PMID: 17222789

Stacpoole (1989) The pharmacology of dichloroacetate. Metabolism Clin.Exp. 38 1124

If you know of a relevant reference for DCA, please let us know.

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关键词: DCA, DCA supplier, Mitochondrial, pyruvate, dehydrogenase, kinase, PDK, inhibitors, inhibits, Kinases, Other, 2755, Tocris Bioscience

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DCA 的评论

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DCA assay.
By Xiaoyu Zhang on 03/08/2024
分析类型： In Vitro
种属： Human
细胞系/组织： 293T

20mM treatment of 293T cells for 24hours. Western blot detects p53 expression after DCA treatment.

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