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(±)-α-Lipoamide

Cat. No. 7045 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

7045 has been discontinued.

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说明： Phase-separated condensate modifier; orally bioavailable
化学名： 1,2-Dithiolane-3-pentanamide
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for (±)-α-Lipoamide

(±)-α-Lipoamide is a phase-separated condensate modifier. Reduces propensity of stress granule proteins to aggregate (EC50 = 20 μM in HeLa and iPSCs), and causes FUS stress granule proteins to return to the nucleus in vitro. Stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of ALS patient-derived (FUS mutant) motor neuron axons in culture, and recovers motor defects in D. melanogaster expressing FUS mutants. Suppresses the effects of ALS-associated FUS mutations in vivo in different systems. Orally bioavailable.

技术数据 for (±)-α-Lipoamide

分子量 205.33
公式 C8H15NOS2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 940-69-2
PubChem ID 863
InChI Key FCCDDURTIIUXBY-UHFFFAOYSA-N
Smiles NC(CCCCC1CCSS1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (±)-α-Lipoamide

分析证书/产品说明书
化学品安全技术说明书

参考文献 for (±)-α-Lipoamide

参考文献是支持产品生物活性的出版物。

Shen et al (2011) Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 162 1213 PMID: 21108628

Wheeler et al (2019) Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease

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