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(±)-α-Lipoic acid

Cat. No. 7044 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Liquid-liquid phase separated condensate modifier; reduces stress granule formation
化学名： 1,2-Dithiolane-3-pentanoic acid
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for (±)-α-Lipoic acid

(±)-α-Lipoic acid (ALA) is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS. (±)-α-Lipoic acid is also an antixocidant. In hematopoietic stem cells (HSC) (±)-α-Lipoic acid reduces levels of reactive oxygen species (ROS) and inhibits apoptosis. It also promotes the generation of hematopoietic stem/progenitor cells from hPSCs in vitro and maintenance of functional cord blood HSCs ex vivo.

技术数据 for (±)-α-Lipoic acid

分子量 206.32
公式 C8H14O2S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1077-28-7
PubChem ID 864
InChI Key AGBQKNBQESQNJD-UHFFFAOYSA-N
Smiles OC(=O)CCCCC1CCSS1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (±)-α-Lipoic acid

分析证书/产品说明书
化学品安全技术说明书

参考文献 for (±)-α-Lipoic acid

参考文献是支持产品生物活性的出版物。

Biewenga et al (1997) The pharmacology of the antioxidant lipoic acid. Gen.Pharmacol. 29 315 PMID: 9378235

Shen et al (2011) Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 162 1213 PMID: 21108628

Wheeler et al (2019) Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. BioRXiv - paper not yet peer reviewed

Dong et al (2020) Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. J.Leukoc.Biol. 108 1711 PMID: 32640500

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