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EM12-SO2F

Cat. No. 7852 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent covalent inhibitor of Cereblon
化学名： 2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride
纯度： ≥95% (HPLC)
说明书
引用文献
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文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for EM12-SO2F

EM12-SO2F is a potent covalent Cereblon (CRBN) inhibitor (IC50 = 0.88 nM). Binds to a histidine residue (His353) in the IMiD binding pocket of CRBN and blocks the recruitment of its substrates. EM12-SO2F prevents Lenalidomide (Cat. No. 6305)-induced degradation of the zinc finger transcription factor IKZF1 in MOLT4 cells. It complements CRBN based PROTAC and genetic methods to validate CRBN-mediated degradation.

技术数据 for EM12-SO2F

分子量 326.3
公式 C13H11FN2O5S
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2803819-61-4
PubChem ID 165670019
InChI Key IAJNULNMWPZFDR-UHFFFAOYSA-N
Smiles O=C1NC(C(CC1)N2C(C3=CC(S(=O)(F)=O)=CC=C3C2)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EM12-SO2F

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.63 100

制备储备液 for EM12-SO2F

以下数据基于产品分子量 326.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.06 mL 15.32 mL 30.65 mL
5 mM 0.61 mL 3.06 mL 6.13 mL
10 mM 0.31 mL 1.53 mL 3.06 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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参考文献 for EM12-SO2F

参考文献是支持产品生物活性的出版物。

Cruite et al (2022) Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem.Biol. 3 1105 PMID: 36128501

If you know of a relevant reference for EM12-SO2F, please let us know.

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关键词: EM12-SO2F, EM12-SO2F supplier, EM12SO2F, inhibitor, inhibitors, inhibit, inhibits, Cereblon, CRBN, His353, PROTAC, Targeted, protein, degradation, TPD, Ubiquitin, E3, Ligases, 7852, Tocris Bioscience

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