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Epiblastin A

Cat. No. 6340 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal
化学名： 6-(3-Chlorophenyl)-2,4,7-pteridinetriamine
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Epiblastin A

Epiblastin A is a CK1 inhibitor (IC50 values are 0.8, 3.7 and 3.8 μM for CK1δ, CK1ε and CK1α). Converts late-stage epiblast stem cells into germline-competent embryonic SC-like cells. Promotes activation and maintenance of the pluripotency network. Promotes ESC self-renewal at a concentration of 2 μM.

化合物库 for Epiblastin A

Epiblastin A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Epiblastin A

分子量 287.71
公式 C12H10CIN7
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 16470-02-3
PubChem ID 118987042
InChI Key ZWNKKZSRANLVEW-UHFFFAOYSA-N
Smiles NC1=NC2=NC(N)=C(C3=CC(Cl)=CC=C3)N=C2C(N)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Epiblastin A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.75 20

制备储备液 for Epiblastin A

以下数据基于产品分子量 287.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 17.38 mL 86.89 mL 173.79 mL
1 mM 3.48 mL 17.38 mL 34.76 mL
2 mM 1.74 mL 8.69 mL 17.38 mL
10 mM 0.35 mL 1.74 mL 3.48 mL

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参考文献 for Epiblastin A

参考文献是支持产品生物活性的出版物。

Illich et al (2016) Distinct signaling requirements for the establishment of ESC pluripotency in late-stage EpiSCs. Cell Rep. 15 787 PMID: 27149845

Ursu et al (2016) Epiblastin A induces reprogramming of epiblast stem cells Into embryonic stem cells by inhibition of casein kinase 1. Cell Chem.Bio. 23 494 PMID: 27049670

If you know of a relevant reference for Epiblastin A, please let us know.

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关键词: Epiblastin A, Epiblastin A supplier, EpiblastinA, CK1, inhibitors, inhibits, casein, kinase, Epiblast, stem, cells, conversion, pluripotency, self, renewal, Casein, Kinase, 1, Stem, Cell, Proliferation, Reprogramming, 6340, Tocris Bioscience

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