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Submit ReviewER 27319 maleate
说明： Selective Syk kinase inhibitor
化学名： 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate
纯度： ≥99% (HPLC)
生物活性 for ER 27319 maleate
ER 27319 maleate is a selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events.
化合物库 for ER 27319 maleate
ER 27319 maleate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for ER 27319 maleate
| 分子量 | 396.17 |
| 公式 | C18H20N2O.C4H4O4 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1204480-26-1 |
| PubChem ID | 56972172 |
| InChI Key | WVUQPGFRFBVJKH-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.CC1=C(C)C2=C(C=C1)C(=O)C1=CC=CC=C1N2CCCN |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ER 27319 maleate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 29.71 | 75 | |
| DMSO | 39.62 | 100 |
制备储备液 for ER 27319 maleate
以下数据基于产品分子量 396.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.62 mL | 25.24 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.05 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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产品说明书 for ER 27319 maleate
参考文献 for ER 27319 maleate
参考文献是支持产品生物活性的出版物。
Luskova and Draber (2004) Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr.Pharm.Des. 10 1727 PMID: 15180535
Moriya et al (1997) ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk. Proc.Natl.Acad.Sci.USA 94 12539
If you know of a relevant reference for ER 27319 maleate, please let us know.
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关键词: ER 27319 maleate, ER 27319 maleate supplier, Selective, Syk, kinases, inhibitors, inhibits, TNF-α, TNF-alpha, production, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, ER27319, maleate, Kinase, 2471, Tocris Bioscience
2 篇 ER 27319 maleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ER 27319 maleate 的部分引用包括：
Rycaj et al (2016) Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells. Oncotarget 7 14220 PMID: 26871947
Ng et al (2008) Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 29 807 PMID: 18993083
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ER 27319 maleate 的评论
平均评分: 5 (Based on 1 Review.)
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Potential candidate to control for expression of the protein of interest.
By
Anonymous on 01/04/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HeLa
In-vitro luciferase assay