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Submit ReviewERGi-USU
说明： Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein
化学名： 1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol
纯度： ≥99% (HPLC)
生物活性 for ERGi-USU
ERGi-USU is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.
技术数据 for ERGi-USU
| 分子量 | 255.3 |
| 公式 | C13H9N3OS |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1147-56-4 |
| PubChem ID | 6308684 |
| InChI Key | GCBAKGGJQPMJLL-QINSGFPZSA-N |
| Smiles | OC1=C(C2=CC=CC=C2C=C1)/N=N/C3=NC=CS3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ERGi-USU
参考文献 for ERGi-USU
参考文献是支持产品生物活性的出版物。
Mohamed et al (2018) Identification of a small molecule that selectively inhibits ERG-positive cancer cell growth. Cancer Res. 78 3659 PMID: 29712692
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关键词: ERGi-USU, ERGi-USU supplier, Rio2, kinase, RIOK2, atypical, protein, aPK, ribosome, biogenesis, inhibitors, inhibits, high, affinity, ERG, prostate, cancer, Other, Kinases, 6632, Tocris Bioscience
1 篇 ERGi-USU 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ERGi-USU 的部分引用包括：
Marc et al (2021) Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer. Elife 10 PMID: 34121659
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