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Submit ReviewFITC-labelled Keap1-Nrf2 probe
说明： Fluorescent Keap1-Nrf2 peptide
纯度： ≥90% (HPLC)
生物活性 for FITC-labelled Keap1-Nrf2 probe
FITC-labelled Keap1-Nrf2 probe is a fluorescent Keap1-Nrf2 peptide (Kd = 22.3 nM). It can be used to assess the binding affinities of Nrf2 peptide inhibitors in Fluorescence Polarization (FP) displacement assays and TR-FRET.
Optical Data for FITC-labelled Keap1-Nrf2 probe
| Emission Color | Green |
|---|---|
| λabs | 495 nm |
| λem | 525 nm |
| Closest Laser line | 488 nm |
| Application | Fluorescence polarization (FP) displacement assays, TR-FRET |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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技术数据 for FITC-labelled Keap1-Nrf2 probe
| 分子量 | 1440.5 |
| 公式 | C67H81N11O23S |
| 序列 |
LDEETGEFL (Modifications: Leu-1 = FITC-Leu, Leu-9 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥90% (HPLC) |
| InChI Key | RDECLUWFJCNNAY-NZNAQQBOSA-N |
| Smiles | O=C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](NC(NC(C=C2C(O)=O)=CC=C2C(C3=C4C=C(O)C=C3)=C(C=C5)C(O4)=CC5=O)=S)CC(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FITC-labelled Keap1-Nrf2 probe
参考文献 for FITC-labelled Keap1-Nrf2 probe
参考文献是支持产品生物活性的出版物。
Chen et al (2011) Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem.Biol.Drug Des. 78 1014 PMID: 21920027
Inoyama et al (2012) Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. J.Biomol.Screen 17 435 PMID: 22156223
Wang et al (2020) Development of an enzyme-linked immunosorbent assay for Keap1-Nrf2 interaction inhibitors identification. Redox Biol. 34 101573 PMID: 32422542
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关键词: FITC-labelled Keap1-Nrf2 probe, FITC-labelled Keap1-Nrf2 probe supplier, Fluorescent, Fluorescence, polarization, FP, displacement, assays, Keap1, Nrf2, ARE, pathway, peptide, transcription, factor, TR-FRET, Ubiquitin, E3, Ligases, Enzyme, Probes, and, Substrates, Assay, Reagents, 7627, Tocris Bioscience
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