Fludarabine

Name: Fludarabine
Brand: Tocris Bioscience
SKU: 3495
Rating: 5 (1 reviews)

Cat. No. 3495 10 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Purine analog; inhibits DNA synthesis

化学名： 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine

纯度： ≥98% (HPLC)

说明书

引用文献 (10)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Fludarabine

Fludarabine is a purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC₅₀ = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.

化合物库 for Fludarabine

Fludarabine is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Fludarabine

分子量	285.23
公式	C₁₀H₁₂FN₅O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	21679-14-1
PubChem ID	657237
InChI Key	HBUBKKRHXORPQB-FJFJXFQQSA-N
Smiles	O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC(F)=NC(N)=C2N=C3)[C@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Fludarabine

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	28.52	100

制备储备液 for Fludarabine

以下数据基于产品分子量 285.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.51 mL	17.53 mL	35.06 mL
5 mM	0.7 mL	3.51 mL	7.01 mL
10 mM	0.35 mL	1.75 mL	3.51 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

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产品说明书 for Fludarabine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Fludarabine

参考文献是支持产品生物活性的出版物。

Bellosillo et al (1999) In vitro evaluation of fludar. in combination with cyclophosph. and/or mitoxan. in B-cell chronic lymphocytic leukemia. Blood 94 2836 PMID: 10515887

Meng et al (2007) Antitumor activity of fludar. against human multiple myeloma in vitro and in vivo. Eur.J.Haematol. 79 486 PMID: 17976186

Torella et al (2007) Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am.J.Physiol.Heart Circ.Physiol. 292 H2935 PMID: 17293493

Frank et al (1999) Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat.Med. 5 444 PMID: 10202937

If you know of a relevant reference for Fludarabine, please let us know.

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