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FPA 124

Cat. No. 2926 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Akt/PKB inhibitor
化学名： Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FPA 124

FPA 124 is an Akt/PKB inhibitor (IC50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.

技术数据 for FPA 124

分子量 381.73
公式 C11H9Cl2CuN3O2S
储存 Store at +4°C
CAS Number 902779-59-3
PubChem ID 16034833
InChI Key HZRXQEVFXXQYFS-VBPDOGLUSA-L
Smiles Cl[Cu]Cl.NC(=S)N\N=C\C1=COC2=C(C=CC=C2)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FPA 124

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 3.82 10
ethanol 3.82 10

制备储备液 for FPA 124

以下数据基于产品分子量 381.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 26.2 mL 130.98 mL 261.97 mL
0.5 mM 5.24 mL 26.2 mL 52.39 mL
1 mM 2.62 mL 13.1 mL 26.2 mL
5 mM 0.52 mL 2.62 mL 5.24 mL

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参考文献 for FPA 124

参考文献是支持产品生物活性的出版物。

Barve et al (2006) Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 49 3800 PMID: 16789737

If you know of a relevant reference for FPA 124, please let us know.

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关键词: FPA 124, FPA 124 supplier, Akt, PKB, inhibitors, inhibits, Protein, Kinases, B, FPA124, (Protein, Kinase, B), B/Akt, 2926, Tocris Bioscience

1 篇 FPA 124 的引用文献

引用文献是使用了 Tocris 产品的出版物。 FPA 124 的部分引用包括：

Liddell et al (2016) Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation 13 49 PMID: 26920699

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Pathways for FPA 124

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.